Research and Professional Experience
| 1998–2002 | Research Associate at Department of Chemistry, School of Science, The University of Tokyo |
| 2002–2005 | Lecturer at Department of Chemistry, School of Science, The University of Tokyo |
| 2005–2007 | Associate Professor, Department of Molecular Structure, Institute for Molecular Science |
| 2007– | Professor, Department of Chemistry, School of Science, The University of Tokyo |
| 2014– | Professor, Department of Biological Sciences, Graduate School of Science, The University of Tokyo |
Awards
| 2018 | The Chemical Society of Japan Award for Creative Work for 2018 |
| 2011 | JSPS Prize (Japan Society for the Promotion of Science) |
| 2005 | Young Scientists Award from Minister of MEXT (Ministry of Education, Culture, Science and Technology) |
| 2004 | The Chemical Society of Japan Award for Young Chemists |
Research Interests
- Analytical Chemistry
- Protein Chemistry
Extramural Activities
- Scientific Reports (Springer Nature), Editorial Board Member
- Editor of Analytical Sciences (Journal of Japan Society for Analytical Chemistry)
- Advisory Board Member of Analyst (RSC Journal)
Research Subjects
- Development of methods for imaging biomolecules in living subjects
- Development of methods for controlling biomolecules in living cells
- Library screening of bioactive molecules
Selected Publications
- G. Kawamura, T. Kokaji, K. Kawata, Y. Sekine, Y. Suzuki, T. Soga, Y.Ueda, M. Endo, S. Kuroda and T. Ozawa, Optogenetic decoding of Akt2-regulated cellular metabolic signaling pathways in skeletal muscle cells using transomics analysis. Science Signaling, 16, eabn0782 (2023).
- Y. Ueda, Y. Miura, N. Tomishige, N. Sugimoto, M. Murase, G. Kawamura, N. Sasaki, T. Ishiwata, and T. Ozawa, Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation. Cell Chem. Biol. 29, 1576-1587 (2022).
- Z. Lei, M. Endo, H. Ube, T. Shiraogawa, P. Zhao, K. Nagata, X.-L. Pei, T. Eguchi, T. Kamachi, M. Ehara*, T. Ozawa* and M. Shionoya*, N-Heterocyclic carbene-based C-centered Au(I)-Ag(I) clusters with intense phosphorescence and the ligand-specific, organelle-selective translocation in cells. Nature Commun., 13, 4288 (2022).
- A. Takamura, D. Watanabe, R. Shimada, and T. Ozawa, Comprehensive modeling of bloodstain aging by multivariate Raman spectral resolution with kinetics. Commun. Chem., 2, 115 (2019).
- Optogenetic activation of axon guidance receptors controls direction of
neurite outgrowth. M. Endo, M. Hattori, H. Toriyabe, H. Ohno, H. Kamiguchi, Y. Iino, T. Ozawa,
Sci. Rep., 2016, 6, 23976. - In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy. Y. Nasu, A. Benke, S. Arakawa, G. J. Yoshida, G. Kawamura, S. Manley, S.
Shimizu, and T Ozawa, Sci. Rep.,2016, 6, 27505. - An optogenetic system for interrogating the temporal dynamics of Akt. Y. Katsura, H. Kubota, K. Kunida, A. Kanno, S. Kuroda, T. Ozawa, Sci. Rep., 2015, 5, 14589.
- Sustained Accurate Recording of Intracellular Acidification in Living Tissues with a Photo-controllable Bioluminescent Protein. M. Hattori, S. Haga, H. Takakura, M. Ozaki and T. Ozawa,
Proc. Nat. Acad. Sci. USA, 2013, 110, 9332-9337. - Cyclic Luciferase for Real-Time Sensing of Caspase-3 Activities in Living Mammals, A. Kanno, Y. Yamanaka, H. Hirano, Y. Umezawa and T. Ozawa, Angew. Chem. Int. Ed. 2007, 46, 7595.
- Imaging Dynamics of Endogenous Mitochondrial RNA in Single Living Cells, T. Ozawa, Y. Natori, M. Sato and Y. Umezawa, Nature Methods, 2007, 4, 413.
- High-Throughput Sensing and Noninvasive Imaging of Protein Nuclear Transport by Using Reconstitution of Split Renilla Luciferase, S. B. Kim, T. Ozawa, S. Watanabe, Y. Umezawa, Proc. Natl. Acad. Sci. USA., 2004, 101, 11542.
- A genetic Approach to Identifying Mitochondrial Proteins, T. Ozawa, Y. Sako, M. Sato, T. Kitamura, and Y. Umezawa, Nature Biotechnol., 2003, 21, 287.
- Fluorescent Indicators for Imaging Protein Phosphorylation in Single Living Cells, M. Sato, T. Ozawa, K. Inukai, T. Asano, and Y. Umezawa, Nature Biotechnol., 2002, 20, 287.
- Split Luciferase as an Optical Probe for Detecting Protein–Protein Interactions in Mammalian Cells Based on Protein Splicing, T. Ozawa, A. Kaihara, M. Sato, K. Tachihara and Y. Umezawa, Anal. Chem., 2001, 73, 2516.