Email: tanakam[at]chem.s.u-tokyo.ac.jp
Office: Room 2606A, Chem West Building（campus map）
Tel: 03-5841-4351 (ext: 24351)

Research and Professional Experience

1990-1995	Department of Biology, Faculty of Science, Ibaraki University
1995-1997	Department of Natural and Functional Sciences, Graduate School of Science and Engineering, Ibaraki University
1997-2000	Department of Environmental and Functional Sciences, Graduate School of Science and Engineering, Ibaraki University
2000-2002	Postdoctoral Researcher, Department of Biological Science, Graduate School of Science, Hiroshima University
2002-2004	Postdoctoral Researcher, National Institute of Agricultural Research (INRA) of Rennes (France)
2001-2010	Postdoctoral Researcher, National Research Center for Protozoan Diseases (NRCPD), Obihiro University of Agriculture and Veterinary Medicine
2010-	Postdoctoral Researcher, Department of Chemistry, School of Science, The University of Tokyo

Awards

1997	Zoological Science Award

Research Interests

• Cell Biology
• Molecular Biology

Research Subjects

Development of Bioluminescent Probes for Molecular Imaging

Publications

• Fluorescent H 2 Receptor Squaramide-Type Antagonists: Synthesis, Characterization, and Applications.
  S. Biselli, I. Alencastre, K. Tropmann, D. Erdmann, M. Chen, T. Littmann, A. F. Maia, M. Gomez-Lazaro, M. Tanaka, T. Ozawa, M. Keller, M. Lamghari, A. Buschauer, G. Bernhardt
  ACS Medicinal Chemistry Letters. 11, 1521–1528 (2020). doi: 10.1021/acsmedchemlett.0c00033.
• [³H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H₄ Receptors.
  E. Bartole, T. Littmann, M. Tanaka, T. Ozawa, A. Buschauer, G. Bernhardt
  J. Med. Chem. 62, 8338–8356 (2019). doi: 10.1021/acs.jmedchem.9b01342.
• In Search for NPY Y4R Antagonists: Incorporation of Carbamoylated
  Arginine, Aza-Amino Acids or D-Amino Acids into Oligopeptides Derived
  from the C-Termini of the Endogenous Agonists.
  K. Kuhn, T. Littmann, S. Dukorn, M. Tanaka, M. Keller, T. Ozawa, G. Bernhardt, and A. Buschauer,
  ACS Omega, 2, 3616-3631 (2017).
• Label-free versus conventional cellular assays: functional investigations on the human histamine H1 receptor.
  S. Lieb, T. Littmann, N. Plank, J. Felixberger, M. Tanaka, T. Schafer, S. Krief, S. Elz, K. Friedland, G. Bernhardt, J. Wegener, T. Ozawa and A. Buschauer,
  Pharmacol. Res., 114, 13-26 (2016).
• Cell-based assays and animal models for GPCR drug screening.
  H. Takakura, M Hattori, M. Tanaka, T Ozawa,
  Methods in Molecular Biology, 1272, 257-270 (2015).
• Analysis of temporal patterns of GPCR–β-arrestin interactions using split luciferase-fragment complementation.
  M. Hattori, M. Tanaka, H. Takakura, K, Aoki, K. Miura, T. Anzai and T. Ozawa,
  Molecular Biosystems, 9, 957-964 (2013).
• Stable expression of green fluorescent protein and targeted disruption of thioredoxin peroxidase-1 gene in Babesia bovis with the WR99210/dhfr selection system.
  M. Asada, M. Tanaka, Y. Goto, N. Yokoyama, N. Inoue, S. Kawazu,
  Molecular and Biochemical Parasitilogy, 181(2), 162-170 (2012).
• Cloning and characterization of peroxiredoxin in Babesia bovis.
  M. Tanaka, T. Sakurai, N. Yokoyama, N. Inoue, S. Kawazu,
  Parasitology Reserch, 105, 1473-1477 (2009).
• Establishment of an in vitro transgene expression system in epimastigates of Trypanosoma congolense.
  T. Sakurai, M. Tanaka, S. Kawazu, N. Inoue,
  Parasitology International, 58, 110-113 (2009).
• Molecular cloning of two caspase-like genes from the hard tick Haemaphysalis longicornis.
  M. Tanaka, M. Liao, J. Zhou, Y. Nishikawa, X. Xuan, K. Fujisaki,
  The Journal of Veterinary Medical Science, 69, 85-90 (2007).
• RNA interference of cytosolic leucine aminopeptidase reduces fecundity in the hard tick, Haemaphysalis longicornis.
  T. Hatta, R. Umemiya, M. Liao, H. Gong, T. Harnnoi, M. Tanaka, T. Miyoshi, D. Boldbaatar, B. Battsetseg, J. Zhou, X. Xuan, M. Tsuji, D. Taylor, K. Fujisaki,
  Parasitology Research, 100(4), 847-854 (2007).
• Identification of a follistatin-related protein from the tick Haemaphysalis longicornis and its effect on tick oviposition.
  J. Zhou J, M. Liao, T. Hatta, M. Tanaka, X. Xuan, K. Fujisaki,
  Gene, 372, 191-198 (2006).
• Effect of symbiotic algae on the growth kinetics in dark-grown Paramecium bursaria.
  T. Kadono, K. Shiota, M. Tanaka, T. Kawano, T. Kosaka, H. Hosoya,
  Endocytobiosis and Cell Research, 15, 63-70 (2004).
• Complete elimination of endosymbiotic algae from Paramecium bursaria and its confirmation by diagnostic PCR.
  M. Tanaka, M. Murata-Hori, T. Kadono, T. Kawano, T. Yamada, T. Kosaka, H. Hosoya,
  Acta Protozoologica, 41, 255-261 (2002).
• Correlation of photosynthetic products of symbiotic Chlorella with the mating reactivity rhythms in a mutant strain of Paramecium bursaria.
  M. Tanaka, I. Miwa,
  Zoological Science, 17, 735-742 (2000).
• Significance of photosynthetic products of symbiotic Chlorella to establish the endosymbiosis and to express the mating reactivity rhythm in Paramecium bursaria.
  M. Tanaka, I. Miwa,
  Zoological Science, 13, 685-692 (1996)

Review

• A new bioassay system for detection of chemical substances in environment using green paramecia, Paramecium bursaria.
  M. Tanaka, Y. Ishizaka, H. Tosuji, M. Kunimoto, N. Nishihara, T. Kadono, T. Kawano, T. Kosaka, N. Hosoya, H. Hosoya,
  Environmental Chemistry (Eds, E. Lichtfouse, J. Schwarzbauer, D. Robert), Springer-Verlag, Berlin, 673-680 (2004)