Scientific Reports (Springer Nature), Editorial Board Member
Analytical Sciences (日本分析化学会誌)，Editor
Analyst (RSC Journal), Advisory Board Member
主な研究テーマ
生体分子の可視化および検出法の開発
生体分子の光制御法の開発
生理機能分子のライブラリー探索
主な論文・著書
G. Kawamura, T. Kokaji, K. Kawata, Y. Sekine, Y. Suzuki, T. Soga, Y.Ueda, M. Endo, S. Kuroda and T. Ozawa, Optogenetic decoding of Akt2-regulated cellular metabolic signaling pathways in skeletal muscle cells using transomics analysis. Science Signaling, 16, eabn0782 (2023).
Y. Ueda, Y. Miura, N. Tomishige, N. Sugimoto, M. Murase, G. Kawamura, N. Sasaki, T. Ishiwata, and T. Ozawa, Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation. Cell Chem. Biol.29, 1576-1587 (2022).
Z. Lei, M. Endo, H. Ube, T. Shiraogawa, P. Zhao, K. Nagata, X.-L. Pei, T. Eguchi, T. Kamachi, M. Ehara*, T. Ozawa* and M. Shionoya*, N-Heterocyclic carbene-based C-centered Au(I)-Ag(I) clusters with intense phosphorescence and the ligand-specific, organelle-selective translocation in cells. Nature Commun., 13, 4288 (2022).
A. Takamura, D. Watanabe, R. Shimada, and T. Ozawa, Comprehensive modeling of bloodstain aging by multivariate Raman spectral resolution with kinetics. Commun. Chem., 2, 115 (2019).
Y. Nasu, A. Benke, S. Arakawa, G. J. Yoshida, G. Kawamura, S. Manley, S. Shimizu, T. Ozawa, In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy. Sci Rep. 6 (2016), doi:10.1038/srep27505.
M. Endo, M. Hattori, H. Toriyabe, H. Ohno, H. Kamiguchi, Y. Iino, T. Ozawa, Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth. Sci Rep. 6 (2016), doi:10.1038/srep23976.
Y. Katsura, H. Kubota, K. Kunida, A. Kanno, S. Kuroda, T. Ozawa, An optogenetic system for interrogating the temporal dynamics of Akt. Sci Rep. 5 (2015), doi:10.1038/srep14589.
M. Hattori, S. Haga, H. Takakura, M. Ozaki, T. Ozawa, Sustained accurate recording of intracellular acidification in living tissues with a photo-controllable bioluminescent protein. Proc Natl Acad Sci USA. 110, 9332–9337 (2013).
R. Kojima, H. Takakura, T. Ozawa, Y. Tada, T. Nagano, Y. Urano, Rational Design and Development of Near-Infrared-Emitting Firefly Luciferins Available In Vivo. Angew. Chem. Int. Ed.52, 1175–1179 (2012).
T. Ozawa, Y. Natori, M. Sato, Y. Umezawa, Imaging dynamics of endogenous mitochondrial RNA in single living cells. Nat Methods. 4, 413–419 (2007).
S. B. Kim, T. Ozawa, S. Watanabe, Y. Umezawa, High-throughput sensing and noninvasive imaging of protein nuclear transport by using reconstitution of split Renilla luciferase. Proceedings of the National Academy of Sciences. 101, 11542–11547 (2004).
T. Ozawa, Y. Sako, M. Sato, T. Kitamura, Y. Umezawa, A genetic approach to identifying mitochondrial proteins. Nat Biotechnol. 21, 287–293 (2003).
M. Sato, T. Ozawa, K. Inukai, T. Asano, Y. Umezawa, Fluorescent indicators for imaging protein phosphorylation in single living cells. Nat Biotechnol. 20, 287–294 (2002).
T. Ozawa, A. Kaihara, M. Sato, K. Tachihara, Y. Umezawa, Split Luciferase as an Optical Probe for Detecting Protein−Protein Interactions in Mammalian Cells Based on Protein Splicing. Anal. Chem.73, 2516–2521 (2001).
