小澤 岳昌
OZAWA Takeaki

  • 教授

Email: ozawa[at]chem.s.u-tokyo.ac.jp
居室: 理学部化学西館2606A(学内地図
電話: 03-5841-4351 (内線: 24351)

略歴
平成5年東京大学理学部化学科卒業
平成10年東京大学大学院理学系研究科博士課程修了(博士(理学))
平成10年東京大学大学院理学系研究科化学専攻 助手
平成14年東京大学大学院理学系研究科化学専攻 講師
平成17年自然科学研究機構分子科学研究所 助教授
平成19年東京大学大学院理学系研究科化学専攻 教授
平成26年同生物科学専攻 教授(併任)
受賞等
2018年第35回日本化学会学術賞(社団法人日本化学会)
2011年第7回(平成22年度)日本学術振興会賞
2009年バイオビジネスコンペJAPAN・バイオ先端知賞(武田計測先端知財団)
2005年文部科学大臣表彰若手科学者賞
2004年日本化学会進歩賞
専門
  • 分析化学
  • タンパク質化学
  • ケミカルバイオロジー
学外活動
  • Scientific Reports (Springer Nature), Editorial Board Member
  • Analytical Sciences (日本分析化学会誌),Editor (2015-2020)
  • Analyst (RSC Journal), Advisory Board Member
  • ACS Omega (ACS), Advisory Board Member
  • Applied Spectroscopy Reviews (Taylor &Francis), Advisory Board Member
主な研究テーマ
  1. 生体分子の可視化および検出法の開発
  2. 生体分子の光制御法の開発
  3. 生理機能分子のライブラリー探索
主な論文・著書
  • Nuclear class 3 PI3K co-activates fasting-specific chromatin remodelling. N. F. Henneman, G. Kawamura, Y. Luo, A. Segaloni, C. O. Dias, J. Su, I. Nemazanyy, S. Cam, C. S. Rodrigues, N. Kuperwasser, N. Cagnard, K. Hnia, R. Margueron, D. Lutter, T. Ozawa, G. Panasyuk, Nature Cell Biol., accepted.
  • Optogenetic control of transition to metamorphosis. C. Wang, D. F. Faerberg, Y. Sekine, T. Ozawa, J. J. Tyson, R. A. Marmion, S. Y. Shvartsman, Proc. Natl. Acad. Sci. U.S.A., 123, e2524141123 (2026).
  • Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models. H. Kimura, A. Hasegawa, T. Nishiguchi, H. H. Nguyen, M. Eguchi, M. Kinoshita, Y. Ogawa, T. Ozawa*, R. Abe*, Nature Commun. 16, 8708 (2025).
  • Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging. Y. Nasu, A. Aggarwal, G. Le, C. Vo, Y. Kambe, X. Wang, F. Beinlich, A. Lee, T. Ram, F. Wang, K. Gorzo, Y. Kamijo, M. Boisvert, S. Nishinami, G. Kawamura, T. Ozawa, H. Toda, G. Gordon, S. Ge, H. Hirase, M. Nedergaard, M.-E. Paquet, M. Drobizhev, K. Podgorski, and R. Campbell, Nature Commun., 14, 6598 (2023).
  • Class 3 PI3K participates in nuclear gene transcription and co-activates the circadian clock to promote de novo purine synthesis. C. Alkhoury, N. Henneman, V. Petrenko, Y. Shibayama, A. Segaloni, A. Gadault, I. Nemazanyy, E.L. Guillou, A. D. Wolide, K. Antoniadou, X. Tong, T. Tamaru, T. Ozawa, M. Girard, K. Hnia, D. Lutter, C. Dibner and G. Panasyuk, Nature Cell Biol., 25, 975-988 (2023).
  • Optogenetic decoding of Akt2-regulated cellular metabolic signaling pathways in skeletal muscle cells using transomics analysis. G. Kawamura, T. Kokaji, K. Kawata, Y. Sekine, Y. Suzuki, T. Soga, Y. Ueda, M. Endo, S. Kuroda and T. Ozawa, Science Signaling, 16, eabn0782 (2023).
  • Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation. Y. Ueda, Y. Miura, N. Tomishige, N. Sugimoto, M. Murase, G. Kawamura, N. Sasaki, T. Ishiwata, and T. Ozawa, Cell Chem. Biol. 29, 1576-1587 (2022).
  • N-Heterocyclic carbene-based C-centered Au(I)-Ag(I) clusters with intense phosphorescence and the ligand-specific, organelle-selective translocation in cells. Z. Lei, M. Endo, H. Ube, T. Shiraogawa, P. Zhao, K. Nagata, X.-L. Pei, T. Eguchi, T. Kamachi, M. Ehara*, T. Ozawa* and M. Shionoya*, Nature Commun., 13, 4288 (2022).
  • Sustained accurate recording of intracellular acidification in living tissues with a photo-controllable bioluminescent protein. M. Hattori, S. Haga, H. Takakura, M. Ozaki and T. Ozawa, Proc. Natl. Acad. Sci. USA, 110, 9332-9337 (2013).
  • Imaging dynamics of endogenous mitochondrial RNA in single living cells. T. Ozawa, Y. Natori, M. Sato and Y. Umezawa, Nature Methods, 4, 413-419 (2007).
  • High-Throughput Sensing and Noninvasive Imaging of Protein Nuclear Transport by Using Reconstitution of Split Renilla Luciferase. S. B. Kim#, T. Ozawa#, S. Watanabe, Y. Umezawa, Proc. Natl. Acad. Sci. USA., 101, 11542-11547 (2004).
  • A genetic Approach to Identifying Mitochondrial Proteins. T. Ozawa, Y. Sako, M. Sato, T. Kitamura, and Y. Umezawa, Nature Biotechnol., 21, 287-293 (2003).
  • Fluorescent Indicators for Imaging Protein Phosphorylation in Single Living Cells. M. Sato, T. Ozawa, K. Inukai, T. Asano, and Y. Umezawa, Nature Biotechnol., 20, 287-294 (2002).