田中 みほ
TANAKA Miho

  • 博士研究員

Email: tanakam[at]chem.s.u-tokyo.ac.jp
居室: 理学部化学西館2606A（学内地図）
電話: 03-5841-4351 (内線: 24351)

略歴
平成7年茨城大学理学部生物学科　卒業
平成9年茨城大学大学院理工学研究科　博士前期課程自然機能科学専攻　修了
平成12年茨城大学大学院理工学研究科　博士後期課程環境機能科学専攻　修了
平成12年広島大学大学院理学系研究科細胞生物学研究室　博士研究員
平成14年フランス国立農学研究機構（INRA）レンヌ研究センター　博士研究員
平成16年帯広畜産大学国立原虫病研究センター　研究機関研究員
平成22年東京大学大学院理学系研究科化学専攻分析化学研究室　博士研究員
受賞等
平成9年度日本動物学会論文賞
専門
  • 細胞生物学
  • 分子生物学
主な研究テーマ

生体分子可視化プローブの開発

主な論文・著書
  • Fluorescent H 2 Receptor Squaramide-Type Antagonists: Synthesis, Characterization, and Applications.
    S. Biselli, I. Alencastre, K. Tropmann, D. Erdmann, M. Chen, T. Littmann, A. F. Maia, M. Gomez-Lazaro, M. Tanaka, T. Ozawa, M. Keller, M. Lamghari, A. Buschauer, G. Bernhardt
    ACS Medicinal Chemistry Letters. 11, 1521–1528 (2020). doi: 10.1021/acsmedchemlett.0c00033.
  • [3H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H4 Receptors.
    E. Bartole, T. Littmann, M. Tanaka, T. Ozawa, A. Buschauer, G. Bernhardt
    J. Med. Chem. 62, 8338–8356 (2019). doi: 10.1021/acs.jmedchem.9b01342.
  • In Search for NPY Y4R Antagonists: Incorporation of Carbamoylated
    Arginine, Aza-Amino Acids or D-Amino Acids into Oligopeptides Derived
    from the C-Termini of the Endogenous Agonists.
    K. Kuhn, T. Littmann, S. Dukorn, M. Tanaka, M. Keller, T. Ozawa, G. Bernhardt, and A. Buschauer,
    ACS Omega, 2, 3616-3631 (2017).
  • Label-free versus conventional cellular assays: functional investigations on the human histamine H1 receptor.
    S. Lieb, T. Littmann, N. Plank, J. Felixberger, M. Tanaka, T. Schafer, S. Krief, S. Elz, K. Friedland, G. Bernhardt, J. Wegener, T. Ozawa and A. Buschauer,
    Pharmacol. Res., 114, 13-26 (2016).
  • Cell-based assays and animal models for GPCR drug screening.
    H. Takakura, M Hattori, M. Tanaka, T Ozawa,
    Methods in Molecular Biology, 1272, 257-270 (2015).
  • Analysis of temporal patterns of GPCR–β-arrestin interactions using split luciferase-fragment complementation.
    M. Hattori, M. Tanaka, H. Takakura, K, Aoki, K. Miura, T. Anzai and T. Ozawa,
    Molecular Biosystems, 9, 957-964 (2013).
  • Stable expression of green fluorescent protein and targeted disruption of thioredoxin peroxidase-1 gene in Babesia bovis with the WR99210/dhfr selection system.
    M. Asada, M. Tanaka, Y. Goto, N. Yokoyama, N. Inoue, S. Kawazu,
    Molecular and Biochemical Parasitilogy, 181(2), 162-170 (2012).
  • Cloning and characterization of peroxiredoxin in Babesia bovis.
    M. Tanaka, T. Sakurai, N. Yokoyama, N. Inoue, S. Kawazu,
    Parasitology Reserch, 105, 1473-1477 (2009).
  • Establishment of an in vitro transgene expression system in epimastigates of Trypanosoma congolense.
    T. Sakurai, M. Tanaka, S. Kawazu, N. Inoue,
    Parasitology International, 58, 110-113 (2009).
  • Molecular cloning of two caspase-like genes from the hard tick Haemaphysalis longicornis.
    M. Tanaka, M. Liao, J. Zhou, Y. Nishikawa, X. Xuan, K. Fujisaki,
    The Journal of Veterinary Medical Science, 69, 85-90 (2007).
  • RNA interference of cytosolic leucine aminopeptidase reduces fecundity in the hard tick, Haemaphysalis longicornis.
    T. Hatta, R. Umemiya, M. Liao, H. Gong, T. Harnnoi, M. Tanaka, T. Miyoshi, D. Boldbaatar, B. Battsetseg, J. Zhou, X. Xuan, M. Tsuji, D. Taylor, K. Fujisaki,
    Parasitology Research, 100(4), 847-854 (2007).
  • Identification of a follistatin-related protein from the tick Haemaphysalis longicornis and its effect on tick oviposition.
    J. Zhou J, M. Liao, T. Hatta, M. Tanaka, X. Xuan, K. Fujisaki,
    Gene, 372, 191-198 (2006).
  • Effect of symbiotic algae on the growth kinetics in dark-grown Paramecium bursaria.
    T. Kadono, K. Shiota, M. Tanaka, T. Kawano, T. Kosaka, H. Hosoya,
    Endocytobiosis and Cell Research, 15, 63-70 (2004).
  • Complete elimination of endosymbiotic algae from Paramecium bursaria and its confirmation by diagnostic PCR.
    M. Tanaka, M. Murata-Hori, T. Kadono, T. Kawano, T. Yamada, T. Kosaka, H. Hosoya,
    Acta Protozoologica, 41, 255-261 (2002).
  • Correlation of photosynthetic products of symbiotic Chlorella with the mating reactivity rhythms in a mutant strain of Paramecium bursaria.
    M. Tanaka, I. Miwa,
    Zoological Science, 17, 735-742 (2000).
  • Significance of photosynthetic products of symbiotic Chlorella to establish the endosymbiosis and to express the mating reactivity rhythm in Paramecium bursaria.
    M. Tanaka, I. Miwa,
    Zoological Science, 13, 685-692 (1996)
著書・総説
  • GPCRに作用する化合物のスクリーニング
    服部満, 田中みほ, 小澤岳昌,
    Clinical Neuroscience, 32, 128-129 (2014).
  • A new bioassay system for detection of chemical substances in environment using green paramecia, Paramecium bursaria.
    M. Tanaka, Y. Ishizaka, H. Tosuji, M. Kunimoto, N. Nishihara, T. Kadono, T. Kawano, T. Kosaka, N. Hosoya, H. Hosoya,
    Environmental Chemistry (Eds, E. Lichtfouse, J. Schwarzbauer, D. Robert), Springer-Verlag, Berlin, 673-680 (2004)
  • 生物は時計を複数持っている
    三輪五十二, 田中みほ,
    遺伝５２巻８号 (1998).